Recently, we have developed a digital whole-body PET scanner based on multi-voltage threshold (MVT) digitizers. To mitigate the impact of resolution degrading factors, an accurate system response is calculated by
Monte Carlo simulation, which is computationally expensive. To address the problem, here we improve the
method of using symmetries by simulating an axial wedge region. This approach takes full advantage of intrinsic
symmetries in the cylindrical PET system without significantly increasing the computation cost in the process
of symmetries. A total of 4224 symmetries are exploited. It took 17 days to generate the system maxtrix on
160 cores of Xeon 2.5 GHz. Both simulation and experimental data are used to evaluate the accuracy of system
response modeling. The simulation studies show the full-width-half-maximum of a line source being 2.1 mm and
3.8 mm at the center of FOV and 200 mm at the center of FOV. Experimental results show the 2.4 mm rods in
the Derenzo phantom image, which can be well distinguished.
Xiangyu Sun, Yanzhao Li, Lingli Yang, Shuai Wang, Bo Zhang, Peng Xiao, and Qingguo Xie, "Fast and accurate Monte Carlo-based system response modeling for a digital whole-body PET," Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101321H (Presented at SPIE Medical Imaging: February 16, 2017; Published: 9 March 2017); https://doi.org/10.1117/12.2249738.
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