In this paper, we propose a 3D registration method for retinal optical coherence tomography (OCT) volumes. The proposed method consists of five main steps: First, a projection image of the 3D OCT scan is created. Second, the vessel enhancement filter is applied on the projection image to detect vessel shadow. Third, landmark points are extracted based on both vessel positions and layer information. Fourth, the coherent point drift method is used to align retinal OCT volumes. Finally, a nonrigid B-spline-based registration method is applied to find the optimal transform to match the data. We applied this registration method on 15 3D OCT scans of patients with Choroidal Neovascularization (CNV). The Dice coefficients (DSC) between layers are greatly improved after applying the nonrigid registration.
Qiangding Wei, Fei Shi, Weifang Zhu, Dehui Xiang, Haoyu Chen, and Xinjian Chen, "Nonrigid registration of 3D longitudinal optical coherence tomography volumes with choroidal neovascularization," Proc. SPIE 10133, Medical Imaging 2017: Image Processing, 101330X (Presented at SPIE Medical Imaging: February 13, 2017; Published: 24 February 2017); https://doi.org/10.1117/12.2253999.
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