Ultrasound tomography (UST) is an emerging modality that can offer quantitative measurements of breast density.
Recent breakthroughs in UST image reconstruction involve the use of a waveform reconstruction as opposed to a raybased
reconstruction. The sound speed (SS) images that are created using the waveform reconstruction have a much
higher image quality. These waveform images offer improved resolution and contrasts between regions of dense and
fatty tissues. As part of a study that was designed to assess breast density changes using UST sound speed imaging
among women undergoing tamoxifen therapy, UST waveform sound speed images were then reconstructed for a
subset of participants. These initial results show that changes to the parenchymal tissue can more clearly be visualized
when using the waveform sound speed images. Additional quantitative testing of the waveform images was also
started to test the hypothesis that waveform sound speed images are a more robust measure of breast density than
ray-based reconstructions. Further analysis is still needed to better understand how tamoxifen affects breast tissue.
Mark Sak, Neb Duric, Peter Littrup, Mark Sherman, and Gretchen Gierach, "Ultrasound tomography imaging with waveform sound speed: parenchymal changes in women undergoing tamoxifen therapy," Proc. SPIE 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography, 101390W (Presented at SPIE Medical Imaging: February 16, 2017; Published: 13 March 2017); https://doi.org/10.1117/12.2254472.
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