Magnetic nanotubes hold the potential for neuroscience applications because of their capability to deliver chemicals or biomolecules and the feasibility of controlling the orientation or movement of these magnetic nanotubes by an external magnetic field thus facilitating directed growth of neurites. Therefore, we sought to investigate the effects of laminin treated magnetic nanotubes and external alternating magnetic fields on the growth of dorsal root ganglion (DRG) neurons in cell culture. Magnetic nanotubes were synthesized by a hydrothermal method and characterized to confirm their hollow structure, the hematite and maghemite phases, and the magnetic properties. DRG neurons were cultured in the presence of magnetic nanotubes under alternating magnetic fields. Electron microscopy showed a close interaction between magnetic nanotubes and the growing neurites Phase contrast microscopy revealed live growing neurons suggesting that the combination of the presence of magnetic nanotubes and the alternating magnetic field were tolerated by DRG neurons. The synergistic effect, from both laminin treated magnetic nanotubes and the applied magnetic fields on survival, growth and electrical activity of the DRG neurons are currently being investigated.
Mouli Ramasamy, Prashanth Shyam Kumar, and Vijay K. Varadan, "Magnetic nanotubes for drug delivery," Proc. SPIE 10167, Nanosensors, Biosensors, Info-Tech Sensors and 3D Systems 2017, 1016715 (Presented at SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring: March 28, 2017; Published: 24 April 2017); https://doi.org/10.1117/12.2264367.
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