We developed melanoidin nanoparticles for in vivo noninvasive photoacoustic mapping of sentinel lymph nodes, photoacoustic tomography of gastro-intestinal tracts, and photothermal ablation cancer therapy. In addition, we developed cell-integrated poly(ethylene glycol) hydrogels for in vivo optogenetic sensing and therapy. Real-time optical readout of encapsulated heat-shock-protein-coupled fluorescent reporter cells made it possible to measure the nanotoxicity of cadmium-based quantum dots in vivo. Using optogenetic cells producing glucagon-like peptide-1, we performed lightcontrolled diabetic therapy for glucose homeostasis. Finally, we developed a smart contact lens composed of biosensors, drug delivery systems, and power sources for the treatment of diabetes as a model disease.
Do Hee Keum, Songeun Beack, and Sei Kwang Hahn, "Smart photonic materials for theranostic applications," Proc. SPIE 10194, Micro- and Nanotechnology Sensors, Systems, and Applications IX, 101940V (Presented at SPIE Defense + Security: April 10, 2017; Published: 18 May 2017); https://doi.org/10.1117/12.2262322.
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