The emerging field of bioelectronic medicine seeks methods for deciphering and modulating electrophysiological activity in the body to attain therapeutic effects at target organs. Current approaches to interfacing with peripheral nerves and muscles rely heavily on wires, creating problems for chronic use, while emerging wireless approaches lack the size scalability necessary to interrogate small-diameter nerves. Furthermore, conventional electrode-based technologies lack the capability to record from nerves with high spatial resolution or to record independently from many discrete sites within a nerve bundle. We recently demonstrated (Seo et al., arXiV, 2013; Seo et al., Neuron, 2016) "neural dust," a wireless and scalable ultrasonic backscatter system for powering and communicating with implanted bioelectronics. There, we showed that ultrasound is effective at delivering power to mm-scale devices in tissue; likewise, passive, battery-less communication using backscatter enabled high-fidelity transmission of electromyogram (EMG) and electroneurogram (ENG) signals from anesthetized rats. In this talk, I will review recent developments from my group and collaborators in this area.
Michel M. Maharbiz, "Recent developments in wireless recording from the nervous system with ultrasonic neural dust (Conference Presentation)," Proc. SPIE 10194, Micro- and Nanotechnology Sensors, Systems, and Applications IX, 101942F (Presented at SPIE Defense + Security: April 13, 2017; Published: 12 June 2017); https://doi.org/10.1117/12.2264062.5459357436001.
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