Long-range surface plasmon waveguides, and their application to various transducer architectures for amplitude- or
phase-sensitive biosensing, are discussed. Straight and Y-junction waveguides are used for direct intensity-based
detection, whereas Bragg gratings and single-, dual- and triple-output Mach Zehnder interferometers are used for phasebased
detection. In either case, multiple-output biosensors which provide means for referencing are very useful to
eliminate common perturbations and drift. Application of the biosensors to disease detection in complex fluids is
discussed. Application to biomolecular interaction analysis and kinetics extraction is also discussed.
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