Fluorescence imaging provides a powerful approach to study fundamental life processes and has become an integral part of the toolbox for biologists. In this talk, I will present optical nanosensors as a new tool; and how we push it to the limit for the applications of translational medicine. Two examples will be given to represent two distinct architectures to solve medical problems at single molecule and single cell level, respectively. The first example is a “lab-on-a-chip” device that can measure binding kinetics between two single molecules without fluorescent labeling. The second example is a “lab-on-a-tip” device that monitors protein expressions in single living cells over time. These nanosensor approaches, complementary to fluorescent imaging, will broaden our understanding of basic life processes at molecular level and will provide new ways for drug discovery and disease diagnostics.
Qimin Quan, "Single-cell and single-molecule biosensing with optical nanosensors (Conference Presentation)," Proc. SPIE 10347, Optical Trapping and Optical Micromanipulation XIV, 103470P (Presented at SPIE Nanoscience + Engineering: August 06, 2017; Published: 29 September 2017); https://doi.org/10.1117/12.2275796.5593138344001.
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