From Event: SPIE Optical Engineering + Applications, 2017
The implementation of X-Ray Phase Contrast (XPC) imaging at synchrotrons has demonstrated transformative potential on a wide range of applications, from medicine and biology to materials science. However, translation to conventional laboratory sources has proven more problematic, because of XPC’s stringent requirements in terms of spatial coherence. This has imposed the use of either micro-focal sources, or collimators (e.g. source gratings) where sources with extended focal spots were used. This reduces the available x-ray flux leading to long exposure times, which is often exacerbated by the use of additional optical elements that need to be scanned during image acquisition. Where these elements are placed downstream of the object, they also lead to an increase in the delivered dose.
XPC has also been successfully adapted to full 3D, computed tomography (CT) implementations, which has however exacerbated the above concerns in terms of acquisition times and delivered doses.
We tackled this problem by developing an incoherent approach to XPC that works with non micro-focal laboratory sources without requiring any additional collimation. The method uses one or two low aspect ratio x-ray masks that are built on low-absorbing graphite substrates for maximum transmission through the mask apertures. The combination of this with a “single-shot” phase retrieval algorithm has enabled the development of a lab-based XPC-CT system that can perform a full scan in a few minutes while delivering low radiation doses. The talk will briefly describe how the method works, then show application examples including direct comparisons with the synchrotron gold standard.
Alessandro Olivo, Paul C. Diemoz, Marco Endrizzi, Charlotte K. Hagen, Fabio A. Vittoria, Alberto Astolfo, Peter R. T. Munro, Peter Modregger, Gibril K. N. Kallon, Dario Basta, Ian Buchanan, Charlotte Maughan Jones, and Anna Zamir, "Fast and low-dose phase contrast CT with non-microfocal laboratory x-ray sources (Conference Presentation)," Proc. SPIE 10391, Developments in X-Ray Tomography XI, 1039107 (Presented at SPIE Optical Engineering + Applications: August 08, 2017; Published: 19 September 2017); https://doi.org/10.1117/12.2275487.5581154916001.
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