Full-field-swept-source optical coherence tomography is capable of detecting small morphological changes in the living human eye below sub-wavelength range by evaluating the phases. This is used to obtain intrinsic optical signals originating in the photoreceptor outer segment, spatially resolved to single photoreceptors. These were measured ex-vivo in explanted porcine retina as well as in the living human eye. The obtained signals are related to an increase of the optical path length of the outer segments. However, they give no hint wether they are caused by an actual physical expansion of the outer segments or by a changes in the index of refraction. Therefore, systematical measurements were carried out to determine the physical nature and biochemical source of the observed effects.
Clara Pfäffle, Dierck Hillmann, Hendrik Spahr, Bastian Kabuth, and Gereon M. Hüttmann, "Systematic in-vivo investigation of intrinsic optical signals in the photoreceptor outer segment (Conference Presentation)," Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104740Y (Presented at SPIE BiOS: January 28, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2289883.5751470614001.
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