Transcutaneous photobiomodulation of the spinal cord in rodent models has shown therapeutic effects to spinal cord injury. For translation to human medicine; however, it remains unknown if a therapeutic dose can reach the spinal cord with a non-invasive treatment protocol that does not cause collateral tissue damage. Our previous pilot test on a cadaver dog using a single photo-diode-sensor demonstrated that the transcutaneous transmission of 980nm light to the spinal canal through the shallowest section of the vertebrae was comparable to the transcranial transmission. The use of a single sensor to measure at multiple positions along the spinal canal challenged correlations of the results, due to variations of sensor-tissue geometry after repositioning the sensor within the spinal canal and closing the tissue for light transmission. To identify a potential transmission window for delivering an effective photobiomodulation therapy dose to the spinal cord, and to evaluate inter-subject variations, it is essential to maintain consistency in intra-spinal measurements at multiple positions for any one subject and across multiple subjects. We developed a flexible multi-channel photo-detector-array specifically for measuring the transmission of light to the spinal canal at multiple sites under fixed surface irradiation. The probe, with a 1/4" stem, contains 9 photo-diodes spaced 1cm apart allowing measurement over an 8cm length. Multi-site dosimetry at 980nm was tested in one cadaver dog at a fixed surface (shaved skin) irradiance of 3.18 W/cm2 by deploying the applicator-probe in the spinal canal after hemilaminectomy, and will be repeated in a total of six dogs.
Daqing Piao, Lara Sypniewski, Christian Bailey, Danielle Dugat, Shaghayegh Aslanzadeh, Daniel Burba, and Luis H. De Taboada, "Enabling multi-site intra spinal canal dosimetry of transcutaneous photobiomodulation therapy on cadaver dogs using a custom designed, flexible, 9-channel photo-diode probe (Conference Presentation)," Proc. SPIE 10477, Mechanisms of Photobiomodulation Therapy XIII, 1047706 (Presented at SPIE BiOS: January 27, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2284800.5751468305001.
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