Photobiomodulation therapy has been around for several decades with a number of applications increasing every year. However, the exact mechanisms of energy/signal transduction, which lead to the observed changes, and the lack of those in living cells, is still poorly understood. We propose and experimentally implement a novel research platform, which uses a microfluidic chip and controllable excitation condition to precisely initiate the process of photobiomodulation. Resonance Raman spectroscopy is employed to assess the structural transformational stages on different time-scales. We will present our first experimental results and discuss those results with respect to potential therapeutic applications.
Vladislav V. Yakovlev, Michael L. Denton, Cherry C. Gonzalez, and Gary D. Noojin, "Novel approach to elucidate the nature of photomodulation therapy," Proc. SPIE 10477, Mechanisms of Photobiomodulation Therapy XIII, 104770L (Presented at SPIE BiOS: January 27, 2018; Published: 27 February 2018); https://doi.org/10.1117/12.2291358.
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