Surgery is the primary curative option for patients with cancer, with the overall objective of complete resection of all cancerous tissue while avoiding iatrogenic damage to healthy tissue. Simultaneous imaging of weak fluorescence signals from multiple targeted molecular markers under bright surgical illumination is an unmet goal with current intra operating instrument. In this talk, I will describe our recent efforts in solving this intraoperative challenge by drawing inspiration from the visual system of the mantis shrimp – a compact biological system optimized for multispectral imaging. We have successfully designed, tested and clinically translated our bio-inspired imagers by monolithically integrating vertically stacked photodetectors with pixelated interference filters. The sensor is capable of recording color and NIR fluorescence from three different molecular markers and display this information using augmented reality goggles. The sensor resolution is 1280 by 720 and operates at 30 frames per second and has been used to simultaneously image tumor targeted dye IR800 and nerve targeted dye, Oxazine-4. Displaying this information in the operating room is a challenging feat. We have used variety of augmented reality displays and will provide overview of both pre-clinical and clinical translation of this technology.
Viktor Gruev, Missael Garcia, Nan Cui, and Qinru Li, "Bio-inspired near infrared fluorescence sensors: from the ocean to the operating room (Conference Presentation)," Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 104780D (Presented at SPIE BiOS: January 27, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2290502.5751476083001.
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