Ovarian cancer is the most lethal gynecologic malignancy in women. Due to the absence of early symptoms and the lack of effective screening methods, most women are diagnosed at an advanced stage. Large tumors, which are readily seen by surgeons, require no detection assistance, but metastatic tumors, particularly the intraperitoneal-spread tumors, are difficult to identify beaause of their small size, variable morphology, unpredictable location, and similarity to normal tissues. A highly sensitive and specific sprayable fluorogenic probe was thus developed to visualize these hard-to-detect micro tumors. The rapid fluorogenic signal development will allow for a real-time guidance in the operating room.
Ching Tung, "Instantaneous fluorogenic spray for micro tumor detection
(Conference Presentation)," Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 104780R (Presented at SPIE BiOS: January 28, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2290609.5751476591001.
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