Drug resistance of pathogenic microbes is a quickly growing and extremely dangerous health threat. Bacterial infections are one of the most important causes of skin ulcers. The significant increases in the rates of infection with antibiotic- and multi-drug-resistant bacteria in recent years have hindered clinical treatment, but the effect of antibiotics is very disappointing. Therefore, we have applied ALA-PDT in the treatment of refractory infectious ulcers in clinical practice, and find that ALA-PDT is a potential modality to control Pseudomonas aeruginosa infection and can effectively kill Pseudomonas aeruginosaon chronic skin ulcers, and promote healing of chronic skin ulcers. Through in vitro experiments, we have further confirmed the elimination effect of Pseudomonas aeruginosa biofilm by ALA-PDT and its related mechanisms. And our results shows that ALA-PDT kills planktonic P. aeruginosa and viable cells in the biofilm, destroys biofilm structure, reduces virulence factor secretion, and affects QS system gene expression. These results provide further experimental evidence for the use of PDT for the clinical treatment of P. aeruginosa infections.
Xia Lei and Yang Tan, "Effect and mechanisms of photodynamic therapy in treating chronic skin ulcers infected with Pseudomonas aeruginosa
(Conference Presentation)," Proc. SPIE 10479, Light-Based Diagnosis and Treatment of Infectious Diseases, 104790U (Presented at SPIE BiOS: January 30, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2289032.5751488233001.
Conference Presentations are recordings of oral presentations given at SPIE conferences and published as part of the proceedings. They include the speaker's narration with video of the slides and animations. Most include full-text papers. Interactive, searchable transcripts and closed captioning are now available for 2018 presentations, with transcripts for prior recordings added daily.
Search our growing collection of more than 16,000 conference presentations, including many plenaries and keynotes.