QDs synthesized in aqueous medium and functionalized with polyethylene glycol were used as fluorescent probes. They label and monitor living healthy and cancer brain glial cells in culture. Physical-chemical characterization was performed. Toxicological studies were performed by in vivo short and long-term inhalation in animal models. Healthy and cancer glial living cells were incubated in culture media with highly controlled QDs. Specific features of glial cancer cells were enhanced by QD labelling. Cytoplasmic labelling pattern was clearly distinct for healthy and cancer cells. Labelled cells kept their normal activity for same period as non-labelled control samples.
Patricia M. A. Farias, André Galembeck, Raquel Milani, Arnaldo C. D. S. Andrade, and Andreas Stingl, "Long term imaging of living brain cancer cells," Proc. SPIE 10481, Neural Imaging and Sensing 2018, 1048113 (Presented at SPIE BiOS: January 31, 2018; Published: 12 February 2018); https://doi.org/10.1117/12.2290330.
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