We report a novel yet simple 3D-printed tubing holder for characterizing photoacoustic contrast agents. This device supports up to 12 plastic tubing with sample-to-sample spacing as low as 0.3 mm and provides a consistent distance (± 0.12 mm) between the tubing and the transducer, which is critical for validating photoacoustic contrast agents. An immersion media containing both 40% India ink and lipid that mimics tissue scattered the incident irradiation. We further studied different types of tubing and distance between tubing and transducer. Statistical analysis shows that tubing with a larger outside diameter has more inherent signal, and the signal decayed following a linear relationship (R2=0.997) with respect to distance from the laser focal point. We finally provide a computer-assisted drafting code for the community to customize and print their own phantoms.
Santiago J. Arconada-Alvarez, Junxin Wang, Jeanne Lemaster, and Jesse J. Jokerst, "A novel 3D printed phantom for standard characterization of photoacoustic contrast agents (Conference Presentation)," Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI, 1048602 (Presented at SPIE BiOS: January 27, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2301261.5751436514001.
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