Polarized light imaging and optical spectroscopy can be used to distinguish between healthy and diseased tissue. In this study, the design and testing of a single-pixel hyperspectral imaging system that uses differences in the polarization of light reflected from tissue to differentiate between healthy and thermally damaged tissue is discussed. Thermal lesions were created in porcine skin (n = 8) samples using an IR laser. The damaged regions were clearly visible in the polarized light hyperspectral images. Reflectance hyperspectral and white light imaging was also obtained for all tissue samples. Sizes of the thermally damaged regions as measured via polarized light hyperspectral imaging are compared to sizes of these regions as measured in the reflectance hyperspectral images and white light images. Good agreement between the sizes measured by all three imaging modalities was found. Hyperspectral polarized light imaging can differentiate between healthy and damaged tissue. Possible applications of this imaging system include determination of tumor margins during cancer surgery or pre-surgical biopsy.
Joseph A. Peller, Nancy K. Ceja, Amanda J. Wawak, and Susan R. Trammell, "A polarization sensitive hyperspectral imaging system for detection of differences in tissue properties," Proc. SPIE 10487, Multimodal Biomedical Imaging XIII, 104870F (Presented at SPIE BiOS: January 27, 2018; Published: 13 February 2018); https://doi.org/10.1117/12.2290392.
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