We report on the employment of a biodegradable phosphate-based optical fiber as a pH sensing probe in physiological environment. The phosphate-based optical fiber preform was fabricated by the rod-in-tube technique. The fiber biodegradability was first tested in-vitro and then its biodegradability and toxicity were tested in-vivo. Optical probes for pH sensing were prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method. The fluorescence response of the pH-sensor was measured as a ratio of the emission intensities at the excitation wavelengths of 405 and 450 nm.
Ondřej Podrazky, Pavel Peterka, Soňa Vytykáčová, Jana Proboštová, Martin Kuneš, Oleksiy Lyutakov, Edoardo Ceci-Ginistrelli, Diego Pugliese, Nadia G. Boetti, Davide Janner, and Daniel Milanese, "Biomedical and sensing applications of a multi-mode biodegradable phosphate-based optical fiber
," Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880H (Presented at SPIE BiOS: January 27, 2018; Published: 13 February 2018); https://doi.org/10.1117/12.2285148.
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Study of self-shadowing effect as a simple means to realize nanostructured thin films and layers with special attentions to birefringent obliquely deposited thin films and photo-luminescent porous silicon