We present a multifunctional endoscope capable of imaging, fluid delivery and fluid sampling in the alveolar space. The endoscope consists of an imaging fibre bundle fabricated from cost effective OM1 PCVD graded index preforms made for the telecommunications market. These low-cost fibres could potentially make our endoscope disposable after a single use. The performance of our low-cost imaging fibre bundle is shown to be comparable to the current commercial state-of-the-art. The imaging fibre bundle is packaged alongside two channels for the delivery and extraction of fluids. The fluid delivery channels can be used to deliver fluorescent smart probes for the detection of pathogens and to perform a targeted alveolar lavage without the removal of the imaging fibre as is currently standard procedure. Our endoscope is fully biocompatible and with an overall outer diameter of 1.4 mm allowing it to fit into the standard working channel of a bronchoscope. We demonstrate the use of our endoscope in ex-vivo human lungs. We show alveolar tissue and bacterial imaging over two wavelength bands 520 nm – 600 nm and 650 nm – 750 nm both commonly used for bacterial smart probe detection.
James Stone, Tushar Choudhary, Helen Parker, Bethany Mills, Adam Marshall, Debaditya Choudhury, Michael Tanner, Harry A. Wood, Kerrianne Harrington, Jonathan Knight, Tim A. Birks, Kevin Dhaliwal, and Mark Bradley, "A multifunctional endoscope for imaging, fluid delivery and fluid extraction (Conference Presentation)," Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880V (Presented at SPIE BiOS: January 28, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2289555.5751457694001.
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Study of self-shadowing effect as a simple means to realize nanostructured thin films and layers with special attentions to birefringent obliquely deposited thin films and photo-luminescent porous silicon