Breast lesions diagnosis and characterization need additional cost-effective techniques to avoid unnecessary invasive procedures, such as core needle biopsies, in the case of benign tumors. Endogenous fluorescence is an effective method to highlight in situ metabolic and/or structural changes between cancerous and non-cancerous lesions. In this context, we developed an original set-up, consisting of a 405 nm laser diode transmitting light through a 25 Gauge (0.45 mm x 50mm) 14° sharp fibered needle to excite intranodular fluorophores around the needle tip and providing real-time labelfree fluorescence spectral analysis of lesions from 450 nm to 650 nm. The objective was to help radiologists to classify suspicious masses in vivo and in real-time within the lesion. We reported the results of spectral differences between 14 invasive lobular carcinomas and 6 intraductal papilloma enrolled in a clinical study.
Alexis Toullec, Marie-Christine Mathieu, Charlotte Benoit, René Farcy, Christophe Tourasse, Martine Boisserie-Lacroix, Marie-Pierre Fontaine-Aupart, Suzette Delaloge, and Corinne Balleyguier, "25-gauge fibered-needle for label-free fluorescence analysis of breast masses: a first in vivo study," Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 1048810 (Presented at SPIE BiOS: January 28, 2018; Published: 14 February 2018); https://doi.org/10.1117/12.2286902.
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