In this paper we summarize our recent advances in the development of a combined optical coherence tomography (OCT)/ reflectance confocal microscopy (RCM) approach for diagnosing non-melanoma skin cancers and guiding laser ablation therapy. After developing and clinically demonstrating a hand-held probe , our current focus is in adding the capability for generating rapid mosaic images of large areas of the skin (~15 mm x 15mm), as well as on developing a post-processing software that allows for rapid 3-D rendering of the collected data. We are also developing an automated segmentation algorithm that might be used to more objectively assess the depth of the non-melanoma tumors. With these capabilities, our integrated RCM and OCT imaging approach will provide 3-D microscopic views in orthogonally oriented and enfaceoriented planes with a range of resolutions and fields of view, which should further advance optical imaging to noninvasively guide both diagnosis as well as therapy of non-melanoma skin cancers.
. N. Iftimia et al., Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins. J. Biomed. Opt. 22(7), 076006
Nicusor V. Iftimia, Gopi N. Maguluri, Jesung Park, William J. Fox, and Milind Rajadhyaksha, "New advances in RCM-OCT imaging for non-melanoma skin cancer detection and therapy guidance (Conference Presentation)," Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 104890S (Presented at SPIE BiOS: January 31, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2291031.5751446482001.
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