Hepatocellular carcinoma is one of the most common types of liver cancer causing death all over the world. Although early-stage liver cancer can sometimes be treated with partial hepatectomy, liver transplantation, ablation, and embolization, sorafenib treatment is the only approved systemic therapy for advanced HCC. The aim of this research is to develop tools and methods to understand the individuality of hepatocellular carcinoma. Microfluidic cell-culture platform has been developed to observe behavior of single-cells; fluorescence microscopy has been implemented to investigate phenotypic changes of cells. Our preliminary data proved high-level heterogeneity of hepatocellular carcinoma while verifying limited growth of liver cancer cell lines on the silicon wafer.
Hande Karamahmutoglu, Metin Çetin, Tamer Yağcı, and Meltem Elitaş, "Behavior of HepG2 liver cancer cells using microfluidic-microscopy: a preliminary study," Proc. SPIE 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI, 104910Y (Presented at SPIE BiOS: January 29, 2018; Published: 19 February 2018); https://doi.org/10.1117/12.2289863.
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