HIL sensor is used to measure Hemoglobin (Hb), Icterus and Lipemia in plasma. Conventionally, HIL is detected in centrifuged plasma sample using a spectrophotometer. Such centrifuged sample provides uniform sample without impurity and it is possible to use longer optical path lengths in the range of millimeter. In such situations, a spectrophotometer is sufficient to provide signal to quantify the HIL concentrations. In the proposed work, we have demonstrated HIL detection at shorter optical path length and with plasma with slight impurities. A system is developed with multi-LED illumination and an algorithm is developed to retrieve the concentration of free Hb, Icterus and Lipemia from the plasma sample containing impurities such as stray RBCs. In this work, we will discuss about the performance of a multi-LED system and the underlying algorithm.
Kalpesh B. Mehta, Azhar Mohiudeen, Ragavendra M.S., Sudipa Galgalkar, Ishita Chakraborty, and David Ledden, "HIL sensor at shorter optical path length (Conference Presentation)," Proc. SPIE 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI, 1049115 (Presented at SPIE BiOS: January 29, 2018; Published: 15 March 2018); https://doi.org/10.1117/12.2293975.5752209046001.
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