Normal aging is associated with various metabolic and vascular changes. In the brain, the aging leads to an impairment of vessel structure and function. Characterizing the cerebrovascular pathologies with age is of importance to elucidate the underlying mechanism of cognitive decline correlated with blood perfusion. Here, we examine the effect of aging on cerebral microcirculation up to a capillary flow scale. This study uses optical coherence tomography angiography (OCTA) to measure vessel tortuosity, red blood cell (RBC) speed in individual capillaries and capillary density in the sensory-motor cortex of 8 young (3-month-old) and 8 aged (16-month-old) mice under isoflurane anesthesia. The result shows that the surface arterial vessels are more tortuous and the capillary RBC speed is much higher in aged animals old compared with young ones. However, the capillary vessel density is significantly lowered in the aged group than the young group.
Woo June Choi, Yuandong Li, Wei Wei, and Ruikang K. Wang, "OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)," Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930J (Presented at SPIE BiOS: January 29, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2291096.5751465932001.
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