Hypoxia, or low oxygen partial pressure, is a common feature of many solid tumours, associated with therapy resistance and poor prognosis for cancer patients. This chemical feature of the tumour microenvironment represents an imbalance of blood oxygen supply and tissue oxygen demand. Given the prognostic significance of hypoxia, there is a clinical unmet need to provide validated, non-invasive, imaging biomarkers that can be used to detect and monitor the spatiotemporal distribution of hypoxia at the point of cancer diagnosis and during treatment. In this talk, I will give an overview of how photoacoustic imaging can address this unmet need, providing examples from both preclinical studies in mouse models of cancer and clinical studies in human patients.
Sarah E. Bohndiek, "Photoacoustic imaging to probe tumour oxygenation and oxidative stress dynamics (Conference Presentation)," Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930N (Presented at SPIE BiOS: January 29, 2018; Published: 15 March 2018); https://doi.org/10.1117/12.2300504.5752208511001.
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Study of self-shadowing effect as a simple means to realize nanostructured thin films and layers with special attentions to birefringent obliquely deposited thin films and photo-luminescent porous silicon