Photoacoustic computed tomography (PACT) is a non-invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a photoacoustic computed tomography (PACT) system equipped with a high frequency linear array for anatomical and functional imaging of the mouse whole brain. The linear array was rotationally scanned in the coronal plane to achieve the full-view coverage. We investigated spontaneous neural activities in the deep brain by monitoring the hemodynamics and observed strong interhemispherical correlations between contralateral regions, both in the cortical layer and in the deep regions.
Lei Li, Pengfei Zhang, and Lihong V. Wang, "Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo," Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104941H (Presented at SPIE BiOS: January 29, 2018; Published: 19 February 2018); https://doi.org/10.1117/12.2289118.
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