We present a water-proof Microelectromechanical systems (MEMS) based scanning optical resolution Photoacoustic Microscopy (OR-PAM) system and its application in glioma tumor mouse model study. The presented OR-PAM system has high optical resolution (~3 μm) and high scanning speed (up to 50 kHz A-scan rate), which is ideal for cerebral vascular imaging. In this study, the mice with glioma tumor are treated with vascular disrupting agent (VDA). OR-PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.
Renzhe Bi, Ghayathri Balasundaram, Seungwan Jeon, Yang Pu, Hui Chien Tay, Chulhong Kim, and Malini Olivo, "A fast MEMS scanning photoacoustic microscopy system and its application in glioma study," Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942I (Presented at SPIE BiOS: January 31, 2018; Published: 19 February 2018); https://doi.org/10.1117/12.2287330.
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