We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to detect tumors and reveal detailed angiographic information about human breasts. SBH-PACT provides high spatial and temporal resolutions with a deep in vivo penetration depth of over 4 cm. A volumetric breast image can be acquired by scanning the breast within a single breath hold (~15 sec). We imaged a healthy female volunteer and seven breast cancer patients. SBH-PACT clearly identified all tumors by revealing higher blood vessel densities and lower compliance associated with the tumors
Li Lin, Peng Hu, Junhui Shi, Catherine M. Appleton, Konstantin Maslov, and Lihong V. Wang, "Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold," Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942X (Presented at SPIE BiOS: January 31, 2018; Published: 22 March 2018); https://doi.org/10.1117/12.2290987.
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