We propose that antihistamine desloratadine affects lipid content of tissues, a change that can be accessed with Raman and Brillouin spectroscopies. Antihistamines are commonly prescribed to alleviate allergy symptoms. However, reports indicate increase in appetite and weight gain among their possible side effects. This study examines the relationship between the antihistamines’ use and obesity. Four groups of rats consumed regular or high-lipid diets while daily receiving either desloratadine or placebo. We analyzed changes in the chemical composition and local elasticity of skin and adipose tissue samples using Raman and Brillouin spectroscopy respectively. Both the medicated regular-diet group and the non-medicated high-lipid-diet group showed an increase in samples’ elasticity and lipid content compared to the control group that received placebo. Interestingly, the adipose tissues’ elasticity was significantly lower in the high-lipid-diet group receiving daily desloratadine compared to other groups. Raman and Brillouin spectroscopy demonstrated that desloratadine does affect tissues’ lipid content. Antihistamines may contribute to weight gain as shown by an increased lipid content in the medicated regular-diet group. However, it remains unclear why a combination of antihistamines and a high-lipid diet decreased the elasticity of adipose. This observation may indicate a change in the adipose tissue’s density or lipid absorption.
Maria A. Troyanova-Wood, "Assessing the effect of antihistamines in rodents with Raman and Brillouin spectroscopy (Conference Presentation)," Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 104960V (Presented at SPIE BiOS: January 28, 2018; Published: 15 March 2018); https://doi.org/10.1117/12.2291364.5752215488001.
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