A characteristic sign of aging skin is loss of firmness. Current bioinstruments to measure the influence of formulations on skin mechanics are limited in sensitivity and have high operator variability. To address these issues an optical elastography system was developed. Regions of the upper inner bicep were treated with various commercial formulations including wrinkle reducers, firming films, and moisturizers. These regions along with adjacent untreated areas that served as internal controls were imaged with a custom designed optical elastography system. The elastography system employed a polarized 50 mW 532 nm cw laser as an illumination source, a CCD camera imaging the skin at 160 Hz frame rate and a polarization analyzer aligned parallel to the incident beam. The skin was mechanically loaded using compressed air reduced in pressure and modulated using a proportional valve to provide a 1 Hz sinusoidally varying pressure to the skin with a peak force of 0.15 N. Subjects ranging in ages from 19 to 60 years old were recruited with IRB approval. Displacement and strain encoded elastograms were generated simultaneously for the treated and untreated areas. The ratio of the strain response in the two regions was calculated to quantify the relative effect of the skin agents. Significant differences were found in the strain response to the imposed loads between treated and control areas in all age groups and genders. Optical elastography systems such as the one prototyped in this study may prove to be useful for the cosmetics industry for assessing product efficacy.
Robert Maidhof, Abhinav Madhavachandran, Holly Eyrich, Ami Kling, Anindya Majumdar, John Lyga, and Sean J. Kirkpatrick, "In vivo quantification of the effects of skin product formulations on the mechanical stiffness of skin surface layers using optical elastography (Conference Presentation)," Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 1049610 (Presented at SPIE BiOS: January 28, 2018; Published: 15 March 2018); https://doi.org/10.1117/12.2290254.5752218883001.
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