Fluorescence molecular imaging (FMI) has been widely used in many medical fields with small molecule indocyanine green (ICG). However, low signal-background ratio and limited specificity to tumor remain big challenges for FMI. In this study, a novel excitation strategy is proposed on the basis of clinical approved ICG and 18F-FDG. A series of in vitro experiments are designed to reveal the mechanism and results show obvious decreasing of ICG fluorescence intensity with the increasing distance to excitation source. Meanwhile, the ICG fluorescence intensity is proportional to the activity of radiopharmaceutical. Results from different respects illustrate the promising of this proposed excitation strategy.
Zeyu Zhang, Hongbo Guo, Zhenhua Hu, and Jie Tian, "A novel small molecule mediate 18F-FDG excited fluorescence molecular imaging," Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 1049705 (Presented at SPIE BiOS: January 29, 2018; Published: 20 February 2018); https://doi.org/10.1117/12.2291300.
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