Epithelial breast cells, which are involved in the production of milk fats, display altered lipid metabolism when they grow more malignant. At the same time, breast cancer cells show a higher degree of glycolysis, a mechanism to meet an increased demand for biomass as cells proliferate. Somewhat counterintuitively, breast cancer cells exhibit lower amounts of stored lipid, while glycolysis rates are up. We have investigated the kinetics of glycolysis, lipid synthesis, and lipid consumption rates in healthy and diseased epithelial breast cells. Using stimulated Raman scattering (SRS) microscopy of deuterated precursors, the cellular chemistry can be followed in space and time, revealing a clear link between glycolytic rate and the kinetics of lipid metabolism.
Eric O. Potma, Jue Hou, Elliot Botvinick, and Bruce J. Tromberg, "Kinetics of lipid metabolism in cancer cells (Conference Presentation)," Proc. SPIE 10504, Biophysics, Biology and Biophotonics III: the Crossroads, 1050406 (Presented at SPIE BiOS: January 28, 2018; Published: 15 March 2018); https://doi.org/10.1117/12.2290754.5752153066001.
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