Fluorescence imaging provides a powerful approach to study fundamental life processes and has become an integral part of the toolbox for biologists. In order to study molecular interactions, single molecule imaging approaches require labeling the molecules with fluorescent reporters. The influence of these fluorescent labels to the molecular interactions have been unknown. In this talk, I will present a hybrid photonic-plasmonic nano-device as a new tool to study molecular interactions at the single molecule level. By coupling a single plasmonic nanoantenna with photonic crystal nanocavity, we can achieve both high quality factor and ultra-small mode volume, thus pushing the detection limit to the single molecule level while keeping the local heating effect at a negligible level.
Qimin Quan, "Single-molecule sensing in a hybrid photonic-plasmonic nanocavity (Conference Presentation)," Proc. SPIE 10535, Integrated Optics: Devices, Materials, and Technologies XXII, 1053503 (Presented at SPIE OPTO: January 29, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2292816.5751551031001.
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