Single-molecule magnetic resonance spectroscopy and imaging is one of the ultimate goals in magnetic resonance and will has great applications in a broad range of scientific areas, from life science to physics and chemistry. To achieve this goal, the spin of a single nitrogen vacancy (NV) center in diamond is proposed as a highly sensitive magnetic-field sensor. Our research keeps on the line from one-dimension spectroscopy to two-dimension spectroscopy at single molecule scale. We and co-workers have successfully done a series of work on one-dimension spectroscopy [1-4]. However, measurement of the magnetic dipole-dipole couplings of a molecule is a missing key step from one-dimension to two-dimension magnetic resonance spectroscopy at nanoscale. Through correlation methods, we succeed to detect the intra-molecule magnetic dipole interaction of (5 nanometer)3 volume samples. In the future, magnetic coupling of a single molecule could be achieved if the coherence property of shallow NV sensor is improved .
 Fazhan Shi, Qi Zhang, Pengfei Wang, Hongbin Sun, Jiarong Wang, Xing Rong, Ming Chen, Chenyong Ju, Friedemann Reinhard, Hongwei Chen, Joerg Wrachtrup, Junfeng Wang, and Jiangfeng Du. Single-protein spin resonance spectroscopy under ambient conditions, Science, 347, 1135 (2015)
 C. Mueller, X. Kong, J. M. Cai, K. Melentijevic, A. Stacey, M. Markham, J. Isoya, S. Pezzagna, J. Meijer, J. F. Du, M. B. Plenio, B. Naydenov, L. P. McGuinness, and F. Jelezko. Nuclear magnetic resonance with single spin sensitivity. Nature Communications, 5:4703 (2014)
 Tobias Staudacher, Fazhan Shi, S. Pezzagna, Jan Meijer, Jiangfeng Du, Carlos A. Meriles, Friedemann Reinhard, Joerg Wrachtrup. Nuclear magnetic resonance spectroscopy on a (5nm)3 volume of liquid and solid samples, Science, 339, 561 (2013)
 Fazhan Shi, Qi Zhang, Boris Naydenov, Fedor Jelezko, Jiangfeng Du, Friedemann Reinhard, and Joerg Wrachtrup. Quantum logic readout and cooling of a single dark electron spin, Phys. Rev. B, 87, 195414 (2013)
 Fazhan Shi, Xi Kong, Pengfei Wang, Fei Kong, Nan Zhao, Renbao Liu, and Jiangfeng Du. Sensing and atomic-scale structure analysis of single nuclear spin clusters in diamond, Nature Physics, 10, 21 (2014)
Jiangfeng Du, "Spin magnetic resonance spectroscopy from billions of molecules to single molecule (Conference Presentation)," Proc. SPIE 10547, Advances in Photonics of Quantum Computing, Memory, and Communication XI, 1054708 (Presented at SPIE OPTO: January 30, 2018; Published: 14 March 2018); https://doi.org/10.1117/12.2298397.5751529301001.
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