X-Ray phase contrast imaging (PCI) is being developed as an alternative to overcome the poor contrast sensitivity of existing attenuation imaging techniques. The “phase sensitivity” can be achieved using a number of phase-enhancing geometries such as free space propagation, grating interferometry and edge illumination (also known as coded aperture) technique. The enhanced contrast in the projected intensities (that combine absorption and phase effect) can vary by object shape, size and its material properties as well as the particular PCI method used. We show a comparison of this signal enhancement for both FSP and coded aperture (CA) PCI. Our data shows that the phase enhancement is significantly higher for CA in comparison to FSP. Our preliminary results indicate that the enhanced phase effect decreases in all PCI techniques with increasing background thickness. Investigations involving signal location and background tissue thickness dependent signal enhancement (and/or loss of this signal) are very important in determining the true benefit of PCI methods in a practical application involving thick organs like breast imaging.
Stefano Vespucci, Cale Lewis, Chan Soo Park, and Mini Das, "Examining phase contrast sensitivity to signal location and tissue thickness in breast imaging," Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 1057324 (Presented at SPIE Medical Imaging: February 15, 2018; Published: 9 March 2018); https://doi.org/10.1117/12.2294968.
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