The diversity in the patient population necessitates a more refined dose reduction approach in cardiac perfusion imaging. We have recently formulated a strategy to better calculate individual and personalized injected doses using the body mass index. The purpose of this study is to present a practical method to evaluate the efficacy of personalizing injected dose employing the polar map methodology. Two hundred and fifty-two normally read patients were used to either determine the personalized dose or to test the dose reduction strategy. Fifty of the test patient studies were altered by inserting perfusion defects in the LV wall. The original or full dose as well as the personalizes dose data were reconstructed using OSEM (Ordered subsets expectation maximization) with attenuation, scatter and spatial resolution compensation. The ROC results show that the personalized dose strategy does not adversely affect the detection of perfusion defects.
P. Hendrik Pretorius, Michael A. King, and Karen L. Johnson, "A practical method to evaluate personalized injected patient dose for cardiac perfusion SPECT imaging: the polar map as a numerical observer," Proc. SPIE 10577, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment, 105770O (Presented at SPIE Medical Imaging: February 12, 2018; Published: 7 March 2018); https://doi.org/10.1117/12.2293658.
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