Enzymes play a crucial role in biochemical processes and are essential for many synthetic processes in industry. In spite of their great catalytic performance and high selectivity for material conversion, their chemical and/or thermal stability is a limiting factor for many processes that opt for a high throughput. Increasing the stability of enzymes thus promises considerable increase in productivity of numerous industrial processes.
A promising pathway for such stability enhancement is the generation of hybrid bioinorganic nanomaterials that show catalytic properties similar to enzymes, but at the same time benefit from the chemical and thermal stability of the inorganic constituent. In this presentation we will show that a combination of inorganic nanoparticles with a surrounding protein shell can indeed mimic a variety of enzyme-analogue reactions in both activity and inhibition. Moreover, the catalytic activity can even be enhanced if the materials are exposed to environmental conditions under which traditional protein-based enzymes become inactive.
Mato Knez, "Enzyme mimetic bio-inorganic nanoparticles (Conference Presentation)," Proc. SPIE 10593, Bioinspiration, Biomimetics, and Bioreplication VIII, 105930R (Presented at SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring: March 07, 2018; Published: 27 March 2018); https://doi.org/10.1117/12.2296546.5758614575001.
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