A dynamic all-optically controlled surface plasmon polartions (SPP) novel high-performance multi-function optical microscope, combining optical microscopic imaging, bio-sensing and surface enhanced Raman Scattering (SERS) in a single microscopic system, is presented in this talk. This new configuration uses phase shift of SPP standing wave generated from sub-wavelength slit arrays embedded in a thin metal film to achieve super-resolution wide-field microscopic imaging; phase sensitive surface plasmon resonance (pSPR) bio-sensing technology based on differential phase measurement between radially polarized (RP) and azimuthally polarized (AP) beams to obtain an ultra-high sensitivity and a wide dynamic range simultaneously; the coupling between the localized surface plasmon (LSP) of metallic nano-particles and SPP virtual probe with longitudinal electric field to significantly improve the sensitivity of SERS system. With the integration of these three technologies in a single microscopic configuration, the system can achieve wide-field super-resolved imaging of biological specimens, ultra-high sensitivity for molecule detection and real-time monitoring for reaction process of biological samples simultaneously, fulfilling the requirement of multi-parameter multi-function real-time in-situ measurement of biological samples. The new microscopic scheme has great importance in real-time dynamic study on nano-scale biological living cells as well as accurate near field mapping.
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