A silicon nanowire waveguide based glucose sensor has been proposed and analyzed. It uses minimal invasive approach to measure the glucose level in a very small blood sample, where, Ethylene-diamine-tetraacetic acid (EDTA) as an anticoagulant, sodium fluoride as preservative and blood sample measurand are added in the ratio of 8:1:1. As the glucose concentration in the blood sample varies, the refractive index (RI) of blood changes, accordingly the refractive index of the solution with 10% blood also gets altered, which in turn to deviated response of the biosensor. The prediction of glucose level is affirmed by taking this solution as a cladding measurand of waveguide. Silicon Nanowire Optical Rectangular Waveguide (SNORW) is proposed for the first time in bio-sensing application for the detection of blood glucose. It works on the principle of detecting changes in refractive index for various concentrations of glucose level ranging from 10 mg/dl to 200 mg/dl. Additionally, SNORW sensor characteristics are compared accordingly with the slot waveguide sensors.
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