In this paper we present the novel compact structure of a multimode interference (MMI) based biosensor. We analyze its working principle, evaluate its expected measurement errors and discuss some possible techniques to reduce them. A full description of phase-error (PE) and cross-talk (CT) for the MMI based biosensor is done. Through simulations we have analyzed the windowing technique and the effect of CCD camera resolution in the reduction of PE and CT. We show that the windowing technique is very effective in reducing PE and CT, where the best results are achieved for the Blackman window with an average improvement coefficient of 1210. The reduction of spectral leakage from this window, due to the high roll-off rate of its side lobs, is dominant against the worse spectral resolution that this window has compared to the others. Increasing the CCD camera resolution from 6 × 103 pixels/m to 18 × 103 pixels/m is associated by a rapid reduction of PE and CT with an average improvement coefficient of 44.4. A further increase in the camera resolution is not necessary as it would increase the cost of the device with a very low profit in measurement accuracy.
Moisi Xhoxhi, Alma Dudia, and Aurel Ymeti, "Analysis of phase error and cross talk for a multimode interference based multichannel biosensor," Proc. SPIE 10680, Optical Sensing and Detection V, 1068016 (Presented at SPIE Photonics Europe: April 25, 2018; Published: 9 May 2018); https://doi.org/10.1117/12.2306625.
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