A polarization sensitive extension was implemented into our bright and dark field optical coherence tomography (BRAD-OCT) system. The few-mode fiber detection enables the analysis of the scattering profiles of biological tissues by sensing the sample backscattering information at larger angles through the different fiber modes, enabling simultaneous detection of the bright and dark field. Since the polarization state of light scattered at different angles strongly depends on the tissue microstructure, the polarization sensitive detection improves the imaging capabilities of BRAD-OCT. The system performance was evaluated in phantoms of differently sized microparticles, showing different polarization characteristics for the different fiber modes. Preliminary analysis has been performed in ex vivo brain tissue, where stokes vectors analysis of the different modal images reconstructed by our BRAD-OCT setup indicates that polarization sensitive in combination with BRAD detection is a promising tool for investigating the scattering properties of biological tissues.
Pablo Eugui , Conrad Merkle, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Martina Muck, Adelheid Wöhrer, Christoph K. Hitzenberger, and Bernhard Baumann, "Simultaneous bright and dark field OCT with a polarization sensitive detection (Conference Presentation)," Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 108671T (Presented at SPIE BiOS: February 06, 2019; Published: 4 March 2019); https://doi.org/10.1117/12.2511454.6008538143001.
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