Full-Field Optical Coherence Tomography (FF-OCT) offers aberration independent resolution. This inherent property makes FF-OCT a promising imaging modality for 3D high-resolution retinal imaging. Nevertheless, ocular aberrations affect signal reduction, imposing Adaptive Optics. Here we investigate the best strategy to compensate for ocular aberrations in our FF-OCT setup, in terms of wavefront measurement and correction. The use of wavefront sensorless approach based on the FF-OCT signal level is investigated. Moreover, a strategy of static wavefront correction in a non-conjugated pupil plane and next to the eye’s pupil, just like spectacles, favoring a compact and non-complex AO design, is also investigated. Additionally, the use of wavefront corrector devices such as an adaptive liquid lens (correcting to defocus and astigmatism) and multi-actuator adaptive lenses (correcting up to the 4th order Zernike polynomial) are evaluated. Finally, we expect the implementation of one or a combination of the studied strategies into our FF-OCT setup to lead to the first in-vivo retinal images obtained using AO-assisted FF-OCT, for different retinal layers with enhanced SNR and a 3D high-resolution.
Pedro Mecê, Peng Xiao, Viacheslav Mazlin, Jules Scholler, Kate Grieve, José-Alain Sahel, Mathias Fink, and Claude Boccara, "Towards lens-based wavefront sensorless adaptive optics full-field OCT for in-vivo retinal imaging (Conference Presentation)," Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 1086722 (Presented at SPIE BiOS: February 06, 2019; Published: 4 March 2019); https://doi.org/10.1117/12.2508630.6008538144001.
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