Nasopharyngeal carcinoma (NPC) is a high incidence cancer in southern China and southeast Asia. For the growth and recurrence are in the concealed pharynx and larynx, NPC is difficult to be early diagnosed and effectively treated. Therefore, it is an ideal way to develop strategy for early targeted diagnosis and treatment. R4FLTV, a peptide which can specifically target human nasopharyngeal carcinoma tumor 5-8F, combined with nanoparticle could realize combination of diagnosis and treatment for subcutaneous 5-8F tumor model and lung metastasis in nude mice. By using pull down technology and protein spectrum analysis technique, we found that the ALDH3A2 could be a receptor and molecular marker in the 5-8F cells which targeted by R4FLTV peptide.

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Shuhong Qi, Lisen Lu, and Zhihong Zhang, "ALDH3A2 as a potential molecular marker for nasopharyngeal carcinoma," Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790A (Presented at SPIE BiOS: February 04, 2019; Published: 7 March 2019); https://doi.org/10.1117/12.2506121.