A non-invasive blood glucose measurement method using quantum cascade lasers (QCLs) oscillated in mid-infrared region is introduced. A mid-infrared spectroscopy system equipped with a combination of QCLs as light sources and hollow-optical fibers as beam delivery media is developed. As a wavelength of QCL, the wavenumber of 1152 cm^-1 that exhibited strong correlation with blood glucose in the optical absorption of human lips is firstly chosen. Then 1186 cm^-1 where glucose shows no absorption is also chosen as a reference to remove effects of the baseline variation. By using the QCL-based system, it is shown that the differential absorption between these wavelengths exhibits high correlation with blood glucose level.

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Y. Matsuura and T. Koyama, "Non-invasive blood glucose measurement using quantum cascade lasers," Proc. SPIE 10926, Quantum Sensing and Nano Electronics and Photonics XVI, 1092606 (Presented at SPIE OPTO: February 03, 2019; Published: 1 February 2019); https://doi.org/10.1117/12.2506845.