Detection of suspicious breast cancer lesion in screening mammography images is an important step for the downstream diagnosis the of breast cancer. A trained radiologist can usually take advantage of multi-view correlation of suspicious lesions to locate abnormalities. In this work, we investigate the feasibility of using a random image pair of the same breast from the same exam for the detection of suspicious lesions. We present a novel approach to utilize a single shot detection system inspired by You only look once (YOLO) v1 to simultaneously process a primary detection view and a secondary view for the localization of lesion in the primary detection view. We used a combination of screening exams from Duke University Hospital and OPTIMAM to conduct our experiments. The Duke dataset includes 850 positive cases and around 10,000 negative cases. The OPTIMAM dataset includes around 350 cases. We observed a consistent left shift of the Free-Response Receiver Operating Characteristic (FROC) curve in the multi-view detection model compared to the single-view detection model. This result is promising for future development of automated lesion detection systems focusing on modern full-field digital mammography (FFDM).

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Yinhao Ren, Rui Hou, Dehan Kong, Yue Geng, Lars J. Grimm, Jeffrey R. Marks, and Joseph Y. Lo, "Multiview mammographic mass detection based on a single shot detection system," Proc. SPIE 10950, Medical Imaging 2019: Computer-Aided Diagnosis, 109500E (Presented at SPIE Medical Imaging: February 17, 2019; Published: 13 March 2019); https://doi.org/10.1117/12.2513136.