We present an efficient quantitative phase imaging camera with a weak diffuser (QPICWD) based on the transport of intensity equation (TIE). The compact QPICWD measures object induced phase delay under low-coherence quasi-monochromatic illumination via examining the deformation of the speckle intensity pattern. Analysing the speckle deformation with an ensemble average of the geometric ow, we can achieve the high-resolution distortion field by the TIE. We present some applications for the proposed design involving nondestructive optical testing of microlens array with nanometric thickness and imaging of fixed and live unstained HeLa cells. Since the designed QPICWD needs no modification of the common bright-field microscope or additional accessories, it may advance QPI as a widely useful tool for biological analysis at subcellular levels.

© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Linpeng Lu, Jiasong Sun, Jialin Zhang, Yao Fan, Qian Chen, and Chao Zuo, "Quantitative phase imaging camera with a weak diffuser based on the transport of intensity equation," Proc. SPIE 10990, Computational Imaging IV, 1099009 (Presented at SPIE Defense + Commercial Sensing: April 14, 2019; Published: 13 May 2019); https://doi.org/10.1117/12.2521367.