From Event: SPIE Defense + Commercial Sensing, 2019
Fourier ptychographic microscopy allows for the collection of images with a high space-bandwidth product at the cost of temporal resolution. In Fourier ptychographic microscopy, the light source of a conventional widefield microscope is replaced with a light-emitting diode (LED) matrix, and multiple images are collected with different LED illumination patterns. From these images, a higher-resolution image can be computationally reconstructed without sacrificing field-of-view. We use deep learning to achieve single-shot imaging without sacrificing the space-bandwidth product, reducing the acquisition time in Fourier ptychographic microscopy by a factor of 69. In our deep learning approach, a training dataset of high-resolution images is used to jointly optimize a single LED illumination pattern with the parameters of a reconstruction algorithm. Our work paves the way for high-throughput imaging in biological studies.
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Vidya Ganapati, "Illumination pattern design with deep learning for single-shot Fourier ptychographic microscopy (Conference Presentation)," Proc. SPIE 10990, Computational Imaging IV, 109900G (Presented at SPIE Defense + Commercial Sensing: April 15, 2019; Published: 13 May 2019); https://doi.org/10.1117/12.2520317.6036139602001.