The synergistic effects of PDT and chemotherapy are well established. however, this effect can be more than simple synergy if the correct balance of photosensitiser and chemotherapy agent is selected. We have also shown that by the careful selection of sensitiser, chemotherapy agent and light dose, there is minimal neurotoxicity which is a clear advantage over surgery in cancer therapy The concept of photochemical internalisation is explored in the previous talk. Here the clinical application is explored in a first in human study of PCI. These results plus some results of a follow up study are presented.

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Colin Hopper, "Initial clinical studies with PCI (Conference Presentation)," Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110703D (Presented at 17th International Photodynamic Association World Congress: July 01, 2019; Published: 14 August 2019); https://doi.org/10.1117/12.2527886.6069259048001.