The skin is a barrier between the environment and the body. When a product is applied to the skin, which constituents are penetrating, how much, how fast, how deep? Until now no technology was available to answer that question.
Based on in vivo Raman spectroscopy, we have developed a method which enables quantitative determination of the skin penetration of molecular substances, expressed in g/cm2 of skin surface.
The method is applicable to water-soluble, alcohol-soluble and lipid-soluble compounds.
Quantitative in vivo analysis of dermal product penetration is important in product development, in toxicology and in dermatological research.
Gerwin J. Puppels, Claudio Nico, Tom C. Bakker-Schut, Johanna de Sterke, and Peter J. Caspers, "Skin penetration of topically applied products: quantitative in vivo analysis by Raman spectroscopy (Conference Presentation)," Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123609 (Presented at SPIE BiOS: February 02, 2020; Published: 9 March 2020); https://doi.org/10.1117/12.2544381.6138711697001.
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